Pradeep Keshavanarayana (he/him)
Single cell mechanics
Endothelial cells dynamics
Finite element methods
Spatial iso-geometric 3D beam elements
Single cells turn away upon cyclic stretch
Tug of war between endothelial cells
Endothelial cells form an inner lining of blood vessels, termed endothelium. They are responsible for regulating the movement of molecules through this layer, permeability, by controlling the dynamics of gaps between cells. Recent discoveries have shown that permeability of the endothelium is high in vascular diseases such as atherosclerosis and even in cancer.
In this project, a continuum level FE model is being developed to understand the dynamics of endothelium when subjected to several loads simultaneously. A mechanics based approach is followed that can simulate the response of endothelium to varying physical and chemical properties of the surroundings. In addition to 2D simulations, the continuum framework allows studies in 3D as well.
P.Keshavanarayana, M.Ruess, R.de Borst. On the monolithic and staggered solution of cell contractility and focal adhesion growth, International Journal for Numerical Methods in Biomedical Engineering, 2018.
[ https://doi.org/10.1002/cnm.3138 ]
P.Keshavanarayana, M.Ruess, R.de Borst. A feedback-loop extended stress fiber growth model with focal adhesion formation, International Journal of Solids and Structures, 2017.
[ https://doi.org/10.1016/j.ijsolstr.2017.08.023 ]
Keshavanarayana, Pradeep (2019) Experimental and numerical investigations of stress fibre reorientation in biological cells. PhD Thesis. [ http://theses.gla.ac.uk/id/eprint/41149 ]
PhD, University of Glasgow, UK 2019
MSc, University of Stuttgart, Germany, 2014
BTech, National Institute of Technology Karnataka, India. 2012