Yin Hoon Chew (she/her)
Living cells have the ability to sense their environment and respond by changing various properties including cell morphology. This is achieved through signalling pathways where series of biochemical reactions occur to eventually (de)activate the expression of genes that regulate the properties. Recent studies analysing single-cell image data have found a relationship between cell morphology and drug resistance in cancer cells but how they relate is largely unknown. Yin Hoon’s project aims to provide some mechanistic understanding of the relationship above so that we could improve drug efficacy. Specifically, she is developing a mathematical model that represents the relevant pathways and processes governing morphology and cell death.
PhD in Systems Biology, University of Edinburgh, 2013